|
KMID : 0369820170470050439
|
|
Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 5 p.439 ~ p.444
|
|
|
Indole-based derivatives effect on rats with polycystic ovary syndrome
|
|
Yaghmaei Parichehreh
Dehestani Babak
Ghorbani Samira
Abbasi Farzaneh
Ebrahim Habibi Azadeh
|
|
|
Abstract
|
|
|
|
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, for which efficient therapies are needed. In this study, PCOS was induced in rats by intraperitoneal administration of testosterone propionate (0.2 mg/kg). Indole-based compounds 5-hydroxy indole-2-carboxylic acid, N-acetyl-tryptophan, Tryptamine, l-Tryptophan and Tryptophol were administered for 8 weeks in the PCOS model, after what histopathological assessment of ovaries was performed. The number of primary follicles, corpus luteum, growing follicles and graafian follicles increased and the number and diameter of ovarian cysts decreased in all treated rats in comparison with untreated group. In conclusion, l-Tryptophan and Tryptophol were most efficient as potential therapeutic molecules.
|
|
|
KEYWORD
|
|
|
Polycystic ovary syndrome, Model, Tryptophan
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|